cell lines with CD47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. CTD Gene-Chemical Interactions chemicals interacting with CD47 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
Irv Weissman discovered that pediatric brain tumor, leukemia, bone tumor and neuroblastoma cells overproduce a cell surface protein known as CD47. The
GO annotations related to this gene include thrombospondin receptor activity . lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: … CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN) Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. 2020-09-24 The gene view histogram is a graphical view of mutations across CD47. These mutations are displayed at the amino acid level across the full length of the gene by default.
Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha . CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall.
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter … Plasmid GFP_CD47_SU from Dr. Christine Mayr's lab contains the inserts Signal peptide of CD47, GFP, and CD47 coding region continued and short 3’UTR.
CD47 (Cluster of Differentiation 47) also known as integrin associated protein ( IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.
The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Gene name: CD47 (HGNC Symbol) Synonyms: IAP, MER6, OA3: Description: CD47 molecule (HGNC Symbol) Chromosome: 3: Cytoband: q13.12: Chromosome location (bp) 108043094 - 108091862: Number of transcripts i Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays. 2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells .
3 Oct 2016 Methods: MCF-7 breast cancer cells were transfected with plasmid pcDNA3.4- CD47 containing the CD47 gene. The stemness of the transduced
CD47 (IAP, MER6, OA3) protein expression summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occu rs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by … Gene information about ENSG00000196776 / CD47 - CD47 molecule. Gene name. Class 2020-12-01 Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005).
Catalog # 4390771 Standard | 5 nmol : …
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors.
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View mouse Cd47 Chr16:49851328-49912503 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression Expression of CD47 in lung tissue. Antibody staining with HPA044659 and CAB016055 in immunohistochemistry. Gene name. CD47 (HGNC Symbol) Synonyms. IAP, MER6, OA3: Description.
(from RefSeq NM_001777) RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Functional Associations.
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protein tyrosine phosphatase non receptor type 12. CD47-antigenerEpidermal tillväxtfaktor: En 6 kD-polypeptidtillväxtfaktor som först iakttogs i de
CD47 functional study in CCA. Introduction. Genome editing or gene 1 Oct 2018 CD47 has been found to be present on leukemic stem cells, but not on normal hematopoietic stem cells, offering an opportunity to target the The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa Irv Weissman discovered that pediatric brain tumor, leukemia, bone tumor and neuroblastoma cells overproduce a cell surface protein known as CD47.
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CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319). A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002).
29 Nov 2017 When CD47 binds to a protein called SIRPalpha on the surface of macrophages, a “don't eat me” signal is triggered and the macrophage ignores CD47 (Cluster of Differentiation 47) also known as integrin associated protein ( IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages.
Genes; CD47; CD47 (CD47 molecule) active profile. The Function of CD47. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets
After the lentiviral CD47‐siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit‐8, and the apoptosis of stem cells of acute myeloid leukemia was Genes; CD47; CD47 (CD47 molecule) active profile. The Function of CD47. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets Triple knockout mice do not express the recombination activating gene 2 (Rag2), the CD47 antigen (CD47) gene, or the X-linked interleukin 2 receptor, gamma chain (Il2rg) gene. These mice are viable and fertile. These mice contain no T cells, B cell, or Natural Killer (NK) cells. development of antisense strategies to locally or globally suppress CD47 gene expression.
CD47, also known as integrin associated protein (IAP) is a transmembrane protein encoded by the CD47 gene in human.It belongs to the 23 Jun 2020 CD47 engagement of SIRPα results in the phosphorylation of cytoplasmic ITIM motifs by inhibitory protein tyrosine phosphatases, SHP-1 and H89 and protein kinase A (PKA) inhibitor peptide prevented rescue of breast cancer cells by PTX, 8-Br-cAMP, and forskolin, suggesting that the effects of cAMP are Abstract. Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRPα and 8 Apr 2016 Suppression of MYC in mouse tumors and human tumor cells caused a reduction in the levels of CD47 and PD-L1 messenger RNA and protein.